منابع مشابه
Human serum amyloid A (SAA)
Serum amyloid A apol ipoprote in family consists of three members that in human beings are coded by different genes: SAA1, SAA2, and SAA4 (reviewed in 1-3). SAA1 and SAA2 are so-called acute phase isoforms. Their expression is increased in response to inflammation. SAA4 is a constitutive isoform, the expression of which does not change during an acute-phase response. In addition, one more relat...
متن کاملFactors Influencing Serum Amyloid Type A (Saa) Concentrations in Horses
The acute phase response (APR) is the reaction that occurs in animals in response to disturbances in hemostasis following tissue damage. In horses, the APR is manifested in a variety of pathological processes of various origins, such as infections caused by bacteria, viruses, parasites, arthritis, burns, chemicals, trauma surgery and stress. Acute phase proteins (APPs) are considered those prot...
متن کاملHeparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation.
Inflammation-related (AA) amyloidosis is a severe clinical disorder characterized by the systemic deposition of the acute-phase reactant serum amyloid A (SAA). SAA is normally associated with the high-density lipoprotein (HDL) fraction in plasma, but under yet unclear circumstances, the apolipoprotein is converted into amyloid fibrils. AA amyloid and heparan sulfate (HS) display an intimate rel...
متن کاملSerum amyloid A3 does not contribute to circulating SAA levels.
Adipose tissue secretes proteins like serum amyloid A (SAA), which plays important roles in local and systemic inflammation. Circulating SAA levels increase in obese humans, but the roles of adipose-derived SAA and hyperlipidemia in this process are unclear. We took advantage of the difference in the inducible isoforms of SAA secreted by adipose tissue (SAA3) and liver (SAA1 and 2) of mice to e...
متن کاملSerum Amyloid A (SAA) as Early Diagnosis of COVID-19 Disease: A Systematic Review and Meta-Analysis
Background and Aim: In December 2019, human-to-human transmission of respiratory illness (pneumonia) with fever and sputum was discovered in the respiratory tract, called COVID-19. Serum amyloid A (SAA) is an acute-phase plasma protein that is considered to be diagnostically superior to CRP in pathological conditions such as viral diseases. Therefore, the study question in this review is whethe...
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ژورنال
عنوان ژورنال: Stroke
سال: 2020
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.120.030064